Based on a study, ingestion of hydrolyzed collagen for 90 days effectively reduces skin aging, reducing wrinkles and improving skin elasticity and hydration.

Collagen supplementation revealed a significant decrease in the stiffness subscore, whereas the pain and functional limitation subscores did not have substantial differences.

Vitamin C-enriched gelatin and hydrolyzed collagen supplementation may improve collagen synthesis when taken 1 hr before exercise.

Recent findings show that collagen peptide supplementation improves pain and function and upregulates metabolic pathways associated with muscle and tendon growth.

Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and benefits joint and general well-being.

The evidence obtained from systematic reviews indicated that oral administration of intact or hydrolyzed collagen improves the clinical manifestation of skin health.

In the last decades, increased knowledge about collagen's organization, structure, and properties (particularly concerning interactions between cells and collagen-based materials) has inspired scientists and engineers to design innovative collagen-based biomaterials and develop novel tissue-engineering products.

This study suggests that increasing the concentration of leucine in an essential amino acid supplement consumed during steady state exercise elicits a greater muscle protein synthesis response during recovery

Whey protein (WP) is a widely consumed nutritional supplement that enhances strength and muscle mass during resistance training (RT) regimens. Muscle protein anabolism is acutely elevated following RT, which WP further enhances.

Dietary protein supplementation significantly enhanced muscle strength and size changes during prolonged RET in healthy adults. Increasing age reduces, and training experience increases the efficacy of protein supplementation during resistance exercise training.

A meta-analysis showed that whey protein might reduce the long and short-term appetite.

A meta-analysis of a control group showed that whey protein supplementation seems to improve body weight, total fat mass, and some CVD risk factors in overweight and obese patients.

Whey protein that contains higher amounts of essential amino acids can considerably modify muscle synthesis. After extensive studies, results showed a significant increase in lean body mass after whey protein supplementation. Researchers found no significant changes between soya protein supplementation and body composition parameters.

Whey, a protein complex derived from milk, is touted as a functional food with several health benefits. The biological components demonstrate a range of immune-enhancing properties. In addition, whey can act as an antioxidant, antihypertensive, antitumor, hypolipidemic, antiviral, antibacterial, and chelating agent. Several clinical trials have successfully concluded using whey to treat cancer, HIV, hepatitis B, cardiovascular disease, osteoporosis, and as an antimicrobial agent.

A study conducted on basketball players during and after training showed that taking whey protein powder can cause changes in hemoglobin, red blood cells, and hematocrit in the human body. So whey protein powder can improve exercise capacity and has an anti-fatigue effect.

Bee bread is characterized by multiple pharmacological properties, proven in vitro and Vivo. Thus, it can be stated that bee bread offers a wide field for exploiting its benefits in the food and pharmaceutical industries.

Treatment with bee bread upregulated testicular antioxidant enzymes, downregulated inflammation and apoptosis, increased proliferating cell nuclear antigen (PCNA) immunoexpression and improved lactate transport.

The in vitro digestion results showed that the bioactive compounds in bee pollen and bee bread generally tended to decrease throughout digestion, with some exceptions.

A study provided evidence that honey and bee pollen may improve the menopausal symptoms of breast cancer patients on antihormonal treatment.

During research refeeding diets that contained fresh monofloral bee pollen improved muscle mass and metabolism in old, undernourished rats.

Bacteria of the genus Bacillus have been identified as an essential component of mature and stored BB and dried BP. Moreover, the study's outcomes revealed that BP and BB could be considered potential sources of bacteria-producing antimicrobial agents and/or enzymes of particular industrial importance.

Scientists speculate that various chemical compounds, including hericenones, in the mushroom have multiple effects on the brain's neural networks and improve cognitive functions.

Cordyceps Sinensis has various biological and pharmacological functions, and it has been claimed as a tonic supplement for sexual and reproductive dysfunctions for a long time in oriental society.

Evidence from in vitro and in vivo studies has demonstrated that reishi possesses potential anticancer activity through immunomodulatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic effects.

One of the potential candidates against the SARS-CoV-2 virus may be Inonotus obliquus (IO), also known as Chaga mushroom.

During a study, creatine monohydrate supplementation over ten weeks showed a synergistic effect on aerobic power.

Based on the magnitude inferences, consuming creatine immediately post-workout is superior to pre-workout vis-a-vis body composition and strength.

Preliminary studies indicate that creatine supplementation can increase brain creatine content in humans.

Subsequent studies have demonstrated that cognitive processing, either experimentally (following sleep deprivation) or naturally (due to aging) impaired, can be improved with creatine supplementation.

Scientists have proved that BCAA supplementation before and after exercise has beneficial effects for decreasing exercise-induced muscle damage and promoting muscle-protein.synthesis.

Studies showed that BCAA supplementation reduces delayed onset muscle soreness following exercise training.

A study suggests BCAAs are the substrates for synthesizing nitrogenous compounds and serve as signaling molecules regulating metabolism.

Research shows L-Glutamine supplementation, mainly when associated with physical exercises, improves strength and power of knee muscles.

Vitamin D supplementation may be useful in hypercholesterolemia patients with vitamin D insufficiency who are at high risk of cardiovascular diseases.

A study showed that vitamin D supplementation was safe and protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient, and those not receiving bolus doses experienced the most benefit.

Observational studies report higher blood pressure (BP) among individuals with lower 25-hydroxyvitamin D concentration.

Results of a self-report measure showed that vitamin D3 significantly enhanced positive affect and there was some evidence of a reduction in negative affect when dealing with seasonality.

This study suggests that ascorbic acid (Vitamin C) is effective in improving signs of aging in human skin and plays a significant role in wound healing. Specifically, it helps reduce the appearance of wrinkles and minimizes elevated scars, indicating its beneficial effects on both anti-aging and skin repair processes.

This study suggests that sodium acetylated hyaluronate penetrates deeper into the skin, and protects the dermis from both intrinsic aging and external factors like UV and pollution. It inhibits collagen-degrading enzymes, reducing wrinkle formation and smoothing skin texture, making it effective for anti-aging skincare.

Magnesium supplementation has proven benefits for treating symptoms of daily psychological stress (fatigue, irritability, sleep). It has been shown that subjects with mental and physical stress can benefit from a daily magnesium intake.

Various dietetic investigations have shown that many people (about 20%) constantly consume lower quantities of Mg than recommended; moreover, in this category, a lower bone mineral density and a higher fracturing risk have been found.

This study suggests that lower dietary magnesium intake was associated with higher BP and stroke risk, which may have implications for primary prevention.

Based on magnesium’s many functions within the human body, it plays an essential role in preventing and treating many diseases. Low magnesium levels have been associated with many chronic conditions, such as Alzheimer’s disease, insulin resistance and type-2 diabetes mellitus, hypertension, cardiovascular disease (e.g., stroke), migraine headaches, and attention deficit hyperactivity disorder (ADHD).

In conducted studies, moringa leaves have reduced glycemia without causing any adverse effects. The proposed mechanisms for reducing glycemia include inhibition of α-amylase and α-glucosidase activities, increased glucose uptake in the muscles and liver, inhibition of glucose uptake from the intestine, decreased gluconeogenesis in the liver, and increased insulin secretion and sensitivity.

Various animal studies have assessed the general safety of moringa extracts and have demonstrated a very high degree of safety.

Moringa possesses a wide range of medicinal and therapeutic properties through executing its potent anti-inflammatory activity, inhibiting the activation of NF-κB and PI3K/Akt pathways, mitigating oxidative stress by scavenging free radicals, and enhancing neuroprotective roles. In addition, Moringa can reduce the risk of cancer and modulate blood glucose. Therefore, Moringa provides the potential for the prevention or treatment of a series of chronic diseases.

Aqueous extract of moringa leaves (MOAE) was administered orally at a 200 mg/kg body weight dosage for 30 days. MOAE treatment showed a significant reduction in lipid peroxidation and lipofuscin pigmentation and elevated serotonin and antioxidant enzymes in the brains of treated groups of aged rats. The present result suggests the protective efficacy of moringa against age-related oxidative stress in the brain.

An improvement in sexual desire was observed with Maca since 8 weeks of treatment.

Treatment with Maca resulted in increased seminal volume, sperm count per ejaculum, motile sperm count, and sperm motility.

A study showed a significant reduction in systolic blood pressure (SBP) following zinc supplementation. However, zinc supplementation had no significant effect on diastolic blood pressure (DBP). In addition, no nonlinear association was found between supplementation dosage and duration with changes in both SBP and DBP.

The results of the present systematic review showed that the consumption of T Terrestris L., in general, resulted in the improvement of sperm parameters.

Based on magnesium’s many functions within the human body, it plays an essential role in preventing and treating many diseases. Low magnesium levels have been associated with many chronic conditions, such as Alzheimer’s disease, insulin resistance and type-2 diabetes mellitus, hypertension, cardiovascular disease (e.g., stroke), migraine headaches, and attention deficit hyperactivity disorder (ADHD).

A study provides sufficient evidence to support clinical trials that could eventually lead to curcumin's acceptance as standard therapy for many forms of arthritis and possibly other inflammatory conditions.

A study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption, and bioavailability of curcumin in both rats and humans with no adverse effects.

Eleven studies were made to evaluate the effects of oral turmeric supplementation in the treatment of chronic inflammatory skin diseases. The skin conditions examined include psoriasis, pruritus, oral lichen planus, facial redness, and types of skin cancers. Overall, oral turmeric supplementation has shown therapeutic benefits for skin health.

The desirable preventive or putative therapeutic properties of curcumin have also been considered to be associated with its antioxidant and anti-inflammatory properties.

Six clinical trials with 377 patients were reviewed In Meta-Analysis, comparing the use of curcumin to placebo. In patients with depression, the pooled standardized mean difference from the baseline Hamilton Rating Scale for Depression supports the significant clinical efficacy of curcumin in ameliorating depressive symptoms. Significant anti-anxiety effects were also reported in 3 of the trials.

According to the Meta-analysis that included seven eligible studies (649 patients), turmeric and curcumin may protect patients at risk of cardiovascular disease (CVD) by improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs.

A study provides evidence for curcumin's anti-inflammatory effects and supports further investigation to confirm dose, duration, and formulation to optimize anti-inflammatory effects in humans with chronic inflammation.